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Estrogen Carcinogenesis: Specific Identification of Estrogen-modified Nucleobase in Breast Tissue from Women

Prolonged exposure to estrogens correlates with increased risk for breast cancer. One explanation is that estrogen metabolites cause mutations by reacting with DNA, leading to depurination. We describe an extraction procedure and a liquid chromatographic tandem mass spectrometric (LC/MS/MS) assay to...

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Detalhes bibliográficos
Main Authors: Zhang, Qiang, Aft, Rebecca L., Gross, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742319/
https://ncbi.nlm.nih.gov/pubmed/18672910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx8001737
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