Differential effects of biologic vs bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT

Aseptic loosening secondary to periprosthetic osteolysis remains a serious orthopaedic problem and the greatest limitation of total joint replacement. This process is caused by wear debris-induced osteoclastic bone resorption, for which effective small molecule (bisphosphonates, BPs) and biologic (R...

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Detalhes bibliográficos
Main Authors: Tsutsumi, Ryosuke, Hock, Colleen, Bechtold, C. Dustin, Proulx, Steven T., Bukata, Susan V., Ito, Hiromu, Awad, Hani, Nakamura, Takashi, O'Keefe, Regis J., Schwarz, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742224/
https://ncbi.nlm.nih.gov/pubmed/18404739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.20620
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