Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G(1 )cell cycle arrest and autophagy

BACKGROUND: Selective cyclooxygenase (COX)-2 inhibitors elicit anti-proliferative responses in various tumours, however the underlying anti-tumour mechanisms are unclear. Mutational inactivation of the tumour suppressor p53 gene is frequent in malignant gliomas. The role of p53 mutation in the anti-...

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Hlavní autoři: Kang, Khong Bee, Zhu, Congju, Yong, Sook Kwin, Gao, Qiuhan, Wong, Meng Cheong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741461/
https://ncbi.nlm.nih.gov/pubmed/19706164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-66
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