Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn

Prostacyclin is a pulmonary vasodilator and is produced by prostacyclin synthase and stimulates adenylate cyclase (AC) via the prostacyclin receptor (IP) to produce cAMP. Forskolin is a direct stimulant of AC. Phosphodiesterase 3 hydrolyzes cAMP and is inhibited by milrinone. OBJECTIVE: To character...

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Hauptverfasser: Lakshminrusimha, Satyan, Porta, Nicolas F. M., Farrow, Kathryn N., Chen, Bernadette, Gugino, Sylvia F., Kumar, Vasanth H., Russell, James A., Steinhorn, Robin H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741129/
https://ncbi.nlm.nih.gov/pubmed/19057444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PCC.0b013e3181936aee
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