ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling

BACKGROUND: The angiotensin-converting enzyme (ACE) gene contains a common polymorphism based on the insertion (I) or deletion (D) of a 287-bp intronic DNA fragment. The D allele is associated with higher ACE activity, and thus higher angiotensin II levels. Angiotensin II stimulates cardiac fibrosis...

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Hlavní autoři: Watanabe, Hiroshi, Kaiser, Daniel W., Makino, Seiko, MacRae, Calum A., Ellinor, Patrick T., Wasserman, Brian S., Kannankeril, Prince J., Donahue, Brian S., Roden, Dan M., Darbar, Dawood
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740737/
https://ncbi.nlm.nih.gov/pubmed/19648063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2009.05.014
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