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Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage

The new interleukin (IL)-1 family cytokine IL-33 is synthesized as a 30-kDa precursor. Like pro-IL-1β, human pro-IL-33 was reported to be cleaved by caspase-1 to generate an 18-kDa fragment, which is sufficient to activate signaling by the IL-33 receptor T1/ST2. However, the proposed caspase-1 cleav...

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Bibliografische gegevens
Hoofdauteurs: Talabot-Ayer, Dominique, Lamacchia, Céline, Gabay, Cem, Palmer, Gaby
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740567/
https://ncbi.nlm.nih.gov/pubmed/19465481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901744200
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