A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage

The ubiquitin interaction motif-containing protein RAP80 plays a key role in DNA damage response signaling. Using genomic and functional analysis, we established that the expression of the RAP80 gene is regulated in a DNA damage-responsive manner by the master regulator p53. This regulation occurs a...

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Main Authors: Yan, Jun, Menendez, Daniel, Yang, Xiao-Ping, Resnick, Michael A., Jetten, Anton M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740553/
https://ncbi.nlm.nih.gov/pubmed/19433585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013102
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