Invasion of Endothelial Cells by Tissue-invasive M3 Type Group A Streptococci Requires Src Kinase and Activation of Rac1 by a Phosphatidylinositol 3-Kinase-independent Mechanism

Streptococcus pyogenes can cause invasive diseases in humans, such as sepsis or necrotizing fasciitis. Among the various M serotypes of group A streptococci (GAS), M3 GAS lacks the major epithelial invasins SfbI/PrtF1 and M1 protein but has a high potential to cause invasive disease. We examined the...

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Main Authors: Nerlich, Andreas, Rohde, Manfred, Talay, Susanne R., Genth, Harald, Just, Ingo, Chhatwal, Gursharan S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2009
Ábhair:
Mechanisms of Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740457/
https://ncbi.nlm.nih.gov/pubmed/19473989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016501
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