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Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

Fibrotic rigidification following a myocardial infarct is known to impair cardiac output, and it is also known that cardiomyocytes on rigid culture substrates show a progressive loss of rhythmic beating. Here, isolated embryonic cardiomyocytes cultured on a series of flexible substrates show that ma...

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Bibliographische Detailangaben
Hauptverfasser: Engler, Adam J., Carag-Krieger, Christine, Johnson, Colin P., Raab, Matthew, Tang, Hsin-Yao, Speicher, David W., Sanger, Joseph W., Sanger, Jean M., Discher, Dennis E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740334/
https://ncbi.nlm.nih.gov/pubmed/18957515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.029678
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