Balancing Selection of a Frame-Shift Mutation in the MRC2 Gene Accounts for the Outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle

We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle. The resulting frame-shift reveals a premature stop codon that causes nonsense-mediated decay of the mutant messenger RNA, and the...

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Autors principals: Fasquelle, Corinne, Sartelet, Arnaud, Li, Wanbo, Dive, Marc, Tamma, Nico, Michaux, Charles, Druet, Tom, Huijbers, Ivo J., Isacke, Clare M., Coppieters, Wouter, Georges, Michel, Charlier, Carole
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739430/
https://ncbi.nlm.nih.gov/pubmed/19779552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000666
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