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Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats

AIM: To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats. METHODS: Gastric mucosal injury was induced in male Hos:Donryu rats by oral administration of indomethacin at a dose of 48 mg/k...

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Main Authors: Zhang, Xin, Tajima, Koyuki, Kageyama, Kiyoto, Kyoi, Takashi
格式: Artigo
語言:Inglês
出版: The WJG Press and Baishideng 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739341/
https://ncbi.nlm.nih.gov/pubmed/18720540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.14.4784
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