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Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H(2)O(2)-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures

BACKGROUND: Mitochondrial oxidative stress is a contributing factor in the etiology of numerous neuronal disorders. However, the precise mechanism(s) by which mitochondrial reactive oxygen species (ROS) modify cellular targets to induce the death of neurons remains unknown. The goal of this study wa...

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Autors principals: Cantu, David, Schaack, Jerome, Patel, Manisha
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738973/
https://ncbi.nlm.nih.gov/pubmed/19763183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007095
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