Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality

BACKGROUND: PINCH proteins are five LIM domain only adaptor proteins that function as key components of the integrin signaling pathway, and play crucial roles in multiple cellular processes. Two PINCH proteins, PINCH1 and PINCH2, have been described in mammals and share high homology. Both PINCH1 an...

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Main Authors: Liang, Xingqun, Sun, Yunfu, Ye, Maoqing, Scimia, Maria C., Cheng, Hongqiang, Martin, Jody, Wang, Gang, Rearden, Ann, Wu, Chuanyue, Peterson, Kirk L., Powell, Henry C., Evans, Sylvia M., Chen, Ju
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738591/
https://ncbi.nlm.nih.gov/pubmed/19652092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.864686
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