Cowpox Virus Expresses a Novel Ankyrin Repeat NF-κB Inhibitor That Controls Inflammatory Cell Influx into Virus-Infected Tissues and Is Critical for Virus Pathogenesis

Many pathogenic orthopoxviruses like variola virus, monkeypox virus, and cowpox virus (CPXV), but not vaccinia virus, encode a unique family of ankyrin (ANK) repeat-containing proteins that interact directly with NF-κB1/p105 and inhibit the NF-κB signaling pathway. Here, we present the in vitro and...

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Detalhes bibliográficos
Main Authors: Mohamed, Mohamed Ragaa, Rahman, Masmudur M., Rice, Amanda, Moyer, Richard W., Werden, Steven J., McFadden, Grant
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738262/
https://ncbi.nlm.nih.gov/pubmed/19570875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00861-09
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