Host Shutoff Is a Conserved Phenotype of Gammaherpesvirus Infection and Is Orchestrated Exclusively from the Cytoplasm

Lytic infection with the two human gammaherpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), leads to significant depletion of the cellular transcriptome. This host shutoff phenotype is driven by the conserved herpesviral alkaline exonuclease, termed SOX i...

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Hlavní autoři: Covarrubias, Sergio, Richner, Justin M., Clyde, Karen, Lee, Yeon J., Glaunsinger, Britt A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738246/
https://ncbi.nlm.nih.gov/pubmed/19587049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01051-09
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