Balancing Reversion of Cytotoxic T-Lymphocyte and Neutralizing Antibody Escape Mutations within Human Immunodeficiency Virus Type 1 Env upon Transmission

Human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is subject to both neutralizing antibody (NAb) and CD8 T-cell (cytotoxic T-lymphocyte [CTL]) immune pressure. We studied the reversion of the Env CTL escape mutant virus to the wild type and the relationship between the reversion of...

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Main Authors: Peut, Viv, Campbell, Shahan, Gaeguta, Adriana, Center, Rob J., Wilson, Kim, Alcantara, Sheilajen, Fernandez, Caroline S., Purcell, Damian F. J., Kent, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738168/
https://ncbi.nlm.nih.gov/pubmed/19515763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00599-09
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