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Exploring the Mode of Action of Antimicrobial Peptide MUC7 12-Mer by Fitness Profiling of Saccharomyces cerevisiae Genomewide Mutant Collection

The MUC7 12-mer (RKSYKCLHKRCR) is a cationic antimicrobial peptide derived from the human salivary mucin MUC7. To study its effect/mechanism of action on fungi, we performed a fitness screen of a tagged, diploid, homozygous gene deletion mutant pool of the yeast Saccharomyces cerevisiae grown in the...

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書目詳細資料
Main Authors: Lis, Maciej, Fuss, Jason R., Bobek, Libuse A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737854/
https://ncbi.nlm.nih.gov/pubmed/19596888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00668-09
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