RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

We describe the design and characterization of a potent human respiratory syncytial virus (RSV) nucleocapsid gene-specific small interfering RNA (siRNA), ALN-RSV01. In in vitro RSV plaque assays, ALN-RSV01 showed a 50% inhibitory concentration of 0.7 nM. Sequence analysis of primary isolates of RSV...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Alvarez, Rene, Elbashir, Sayda, Borland, Todd, Toudjarska, Ivanka, Hadwiger, Philipp, John, Mathias, Roehl, Ingo, Morskaya, Svetlana Shulga, Martinello, Rick, Kahn, Jeffrey, Van Ranst, Mark, Tripp, Ralph A., DeVincenzo, John P., Pandey, Rajendra, Maier, Martin, Nechev, Lubomir, Manoharan, Muthiah, Kotelianski, Victor, Meyers, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737834/
https://ncbi.nlm.nih.gov/pubmed/19506055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00014-09
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados