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Regulatory T cells sequentially migrate from the site of tissue inflammation to the draining LN to suppress the alloimmune response
To determine site and mechanism of suppression, regulatory T cell (Treg) migration and function were investigated in an islet allograft model. Treg first migrated from blood to the inflammed allografts, this depended on CCR2, CCR4, CCR5, and P- and E-selectin ligands, and was essential for suppressi...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737741/ https://ncbi.nlm.nih.gov/pubmed/19303390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.12.022 |
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