Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31

Mutations in the genes coding for connexin 26 (Cx26) and connexin 31 (Cx31) cause non-syndromic deafness. Here, we provide evidence that mutations at these two connexin genes can interact to cause hearing loss in digenic heterozygotes in humans. We have screened 108 GJB2 heterozygous Chinese patient...

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Detalhes bibliográficos
Main Authors: Liu, Xue Zhong, Yuan, Yongyi, Yan, Denise, Ding, Emilie Hong, Ouyang, Xiao Mei, Fei, Yu, Tang, Wenxue, Yuan, Huijun, Chang, Qing, Du, LiLin, Zhang, Xin, Wang, Guojian, Ahmad, Shoeb, Kang, Dongyang, Lin, Xi, Dai, Pu
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737700/
https://ncbi.nlm.nih.gov/pubmed/19050930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-008-0602-9
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