Neuropathology of Nondemented Aging: Presumptive Evidence for Preclinical Alzheimer Disease

OBJECTIVE: To determine the frequency and possible cognitive effect of histological Alzheimer’s disease (AD) in autopsied older nondemented individuals. DESIGN: Senile plaques (SPs) and neurofibrillary tangles (NFTs) were assessed quantitatively in 97 cases from 7 Alzheimer’s Disease Centers (ADCs)....

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Autori principali: Price, Joseph L., McKeel, Daniel W., Buckles, Virginia D., Roe, Catherine M., Xiong, Chengjie, Grundman, Michael, Hansen, Lawrence A., Petersen, Ronald C., Parisi, Joseph E., Dickson, Dennis W., Smith, Charles D., Davis, Daron G., Schmitt, Frederick A., Markesbery, William R., Kaye, Jeffrey, Kurlan, Roger, Hulette, Christine, Kurland, Brenda F., Higdon, Roger, Kukull, Walter, Morris, John C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737680/
https://ncbi.nlm.nih.gov/pubmed/19376612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.04.002
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