Inhibitors of MyD88-Dependent Proinflammatory Cytokine Production Identified Utilizing a Novel RNA Interference Screening Approach

BACKGROUND: The events required to initiate host defenses against invading pathogens involve complex signaling cascades comprised of numerous adaptor molecules, kinases, and transcriptional elements, ultimately leading to the production of proinflammatory cytokines, such as tumor necrosis factor alp...

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Main Authors: Cho, John S., Kim, Yun C., Morrison, Sherie L.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737626/
https://ncbi.nlm.nih.gov/pubmed/19753301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007029
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