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Proteasomal Regulation of the Hypoxic Response Modulates Aging in C.elegans
The Caenorhabditis elegans von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here we report that loss of VHL-1 significantly i...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737476/ https://ncbi.nlm.nih.gov/pubmed/19372390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1173507 |
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