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The IFN-induced expression of APOBEC3G in human blood brain barrier exerts a potent intrinsic immunity to block HIV-1 entry to central nervous system
In the human genome the APOBEC3 gene has expanded into a tandem array of genes termed APOBEC3A-H. Several members of this family have potent anti-HIV-1 activity. Here we demonstrate that APOBEC-3B/3C/3F and -3G are expressed in all major cellular components of the CNS. Moreover, we show that both IF...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737467/ https://ncbi.nlm.nih.gov/pubmed/17631933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.06.010 |
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