Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these patients possess an impaired acute inflammatory response, which could result in delayed clearance of bacteria penetrating the lining of the bowel and predispose to granuloma formation and chronicity. We teste...

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Auteurs principaux: Smith, Andrew M., Rahman, Farooq Z., Hayee, Bu'Hussain, Graham, Simon J., Marks, Daniel J.B., Sewell, Gavin W., Palmer, Christine D., Wilde, Jonathan, Foxwell, Brian M.J., Gloger, Israel S., Sweeting, Trevor, Marsh, Mark, Walker, Ann P., Bloom, Stuart L., Segal, Anthony W.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737162/
https://ncbi.nlm.nih.gov/pubmed/19652016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091233
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