Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model

BACKGROUND: Protease inhibitors such as ritonavir can cause nausea and vomiting which is the most common reason for discontinuation. Rats react to nauseous and emetic stimuli by increasing their oral intake of non-nutritive substances like kaolin, known as pica behavior. In this study, we evaluated...

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Detalhes bibliográficos
Main Authors: Yuan, Chun-Su, Wang, Chong-Zhi, Mehendale, Sangeeta R, Aung, Han H, Foo, Adela, Israel, Robert J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736972/
https://ncbi.nlm.nih.gov/pubmed/19698111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-6-19
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