Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity

The renin-angiotensin-aldosterone system (RAAS) is a major regulator of blood pressure. The octapeptide angiotensin II (AII) is proteolytically processed from the decapeptide AI by angiotensin-converting enzyme (ACE), and then acts via angiotensin type 1 and type 2 receptors (AT1R and AT2R). Inhibit...

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Bibliografiske detaljer
Main Authors: Platten, Michael, Youssef, Sawsan, Hur, Eun Mi, Ho, Peggy P., Han, May H., Lanz, Tobias V., Phillips, Lori K., Goldstein, Matthew J., Bhat, Roopa, Raine, Cedric S., Sobel, Raymond A., Steinman, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736463/
https://ncbi.nlm.nih.gov/pubmed/19706421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903958106
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