Protein Tyrosine Phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function

BACKGROUND: Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin. Protein tyrosine phosphatase 1B (PTP1B), a major new pharmaceutical target to treat obesity and type II diabetes, constrains leptin’s metabolic actions, but the extent to which PTP1B regulate...

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Detalhes bibliográficos
Main Authors: de Chantemèle, Eric J. Belin, Muta, Kenjiro, Mintz, James, Tremblay, Michel L., Marrero, Mario B., Fulton, David, Stepp, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736363/
https://ncbi.nlm.nih.gov/pubmed/19687357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.853077
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