Structural and Synthetic Investigations of Tanikolide Dimer, a SIRT2 Selective Inhibitor, and Tanikolide Seco Acid from the Madagascar Marine Cyanobacterium Lyngbya majuscula

Tanikolide seco acid 2 and tanikolide dimer 3, the latter a novel and selective SIRT2 inhibitor, were isolated from the Madagascar marine cyanobacterium Lyngbya majuscula. The structure of 2, isolated as the pure R enantiomer, was elucidated by an X-ray experiment in conjunction with NMR and optical...

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Detalhes bibliográficos
Main Authors: Gutiérrez, Marcelino, Andrianasolo, Eric H., Shin, Won Kyo, Goeger, Douglas E., Yokochi, Alexandre, Schemies, Jörg, Jung, Manfred, France, Dennis, Cornell-Kennon, Susan, Lee, Eun, Gerwick, William H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736347/
https://ncbi.nlm.nih.gov/pubmed/19572575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo900578j
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