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Synthetic Studies on Et-743. Assembly of the Pentacyclic Core and a Formal Total Synthesis
A formal total synthesis of the potent anticancer agent Et-743 is described. The tetrahydroisoquinoline core is stereoselectively constructed using a novel radical cyclization of a glyoxalimine. Further elaboration of this core rapidly accessed the pentacyclic core of Et-743, but a mixture of regios...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736329/ https://ncbi.nlm.nih.gov/pubmed/18687003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo801159k |
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