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The Mediator Complex Subunit 1 Enhances Transcription of Genes Needed for Adrenal Androgen Production

There are three enzymes involved in the biosynthesis of the adrenal androgen dehydroepiandrosterone (DHEA) sulfate. Cholesterol side-chain cleavage (CYP11A1) and 17α-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible...

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Autors principals: Nakamura, Yasuhiro, Xing, Yewei, Sasano, Hironobu, Rainey, William E.
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736083/
https://ncbi.nlm.nih.gov/pubmed/19497978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0006
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