Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice

The lack of fetal immune responses to foreign antigens, i.e., fetal immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, the frequency of engraftment following in utero hematopoietic cell transplantation (IUHCT) in the murine model is reduced in a...

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Detalhes bibliográficos
Main Authors: Merianos, Demetri J., Tiblad, Eleonor, Santore, Matthew T., Todorow, Carlyn A., Laje, Pablo, Endo, Masayuki, Zoltick, Philip W., Flake, Alan W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735937/
https://ncbi.nlm.nih.gov/pubmed/19652363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38979
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