Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice

The lack of fetal immune responses to foreign antigens, i.e., fetal immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, the frequency of engraftment following in utero hematopoietic cell transplantation (IUHCT) in the murine model is reduced in a...

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Main Authors: Merianos, Demetri J., Tiblad, Eleonor, Santore, Matthew T., Todorow, Carlyn A., Laje, Pablo, Endo, Masayuki, Zoltick, Philip W., Flake, Alan W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735937/
https://ncbi.nlm.nih.gov/pubmed/19652363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38979
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