Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice

The lack of fetal immune responses to foreign antigens, i.e., fetal immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, the frequency of engraftment following in utero hematopoietic cell transplantation (IUHCT) in the murine model is reduced in a...

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Bibliografiske detaljer
Main Authors: Merianos, Demetri J., Tiblad, Eleonor, Santore, Matthew T., Todorow, Carlyn A., Laje, Pablo, Endo, Masayuki, Zoltick, Philip W., Flake, Alan W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735937/
https://ncbi.nlm.nih.gov/pubmed/19652363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38979
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