Diet-Genotype Interactions in the Development of the Obese, Insulin-Resistant Phenotype of C57BL/6J Mice Lacking Melanocortin-3 or -4 Receptors

Loss of brain melanocortin receptors (Mc3rKO and Mc4rKO) causes increased adiposity and exacerbates diet-induced obesity (DIO). Little is known about how Mc3r or Mc4r genotype, diet, and obesity affect insulin sensitivity. Insulin resistance, assessed by insulin and glucose tolerance tests, Ser(307)...

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Päätekijät: Sutton, Gregory M., Trevaskis, James L., Hulver, Matthew W., McMillan, Ryan P., Markward, Nathan J., Babin, M. Josephine, Meyer, Emily A., Butler, Andrew A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735103/
https://ncbi.nlm.nih.gov/pubmed/16469808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2005-1209
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