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Potential Oral Delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly (amidoamine) Dendrimers

PURPOSE: To investigate potential application of poly(amidoamine) (PAMAM) dendrimers for improving the delivery of SN-38. METHODS: Complexes of SN-38 with generation 4 amine terminated PAMAM dendrimers were synthesized with varying amounts of drug. Stability of the complexes as well as influence of...

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Hlavní autoři: Kolhatkar, Rohit B., Swaan, Peter, Ghandehari, Hamidreza
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734974/
https://ncbi.nlm.nih.gov/pubmed/18438703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9572-9
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