Functional mapping of the fission yeast DNA polymerase δ B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis

BACKGROUND: DNA polymerase δ plays an essential role in chromosomal DNA replication in eukaryotic cells, being responsible for synthesising the bulk of the lagging strand. In fission yeast, Pol δ is a heterotetrameric enzyme comprising four evolutionarily well-conserved proteins: the catalytic subun...

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Hauptverfasser: Sanchez Garcia, Javier, Baranovskiy, Andrey G, Knatko, Elena V, Gray, Fiona C, Tahirov, Tahir H, MacNeill, Stuart A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734569/
https://ncbi.nlm.nih.gov/pubmed/19686603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-82
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