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Genotype-Phenotype Relationship in Patients with Mutations in Thyroid Hormone Transporter MCT8

Loss-of-function mutations in thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe X-linked psychomotor retardation and elevated serum T(3) levels. Most patients, for example those with mutations V235M, S448X, insI189, or delF230, cannot stand, walk, or speak. Patients wit...

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Detalhes bibliográficos
Main Authors: Jansen, Jurgen, Friesema, Edith C. H., Kester, Monique H. A., Schwartz, Charles E., Visser, Theo J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734492/
https://ncbi.nlm.nih.gov/pubmed/18187543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1475
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