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Cardiac Muscle Protein Catabolism in Diabetes Mellitus: Activation of the Ubiquitin-Proteasome System by Insulin Deficiency

Protein degradation is increased by both insulin deficiency and insulin resistance in humans and animal models. In skeletal muscle this insulin-dependent increase in protein degradation involves activation of both caspase-3 and the ubiquitin-proteasome system. The influence of abnormal insulin signa...

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Bibliografiske detaljer
Main Authors: Hu, Junping, Klein, Janet D., Du, Jie, Wang, Xiaonan H.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734490/
https://ncbi.nlm.nih.gov/pubmed/18653708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0132
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