Talampanel With Standard Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma: A Multicenter Phase II Trial

PURPOSE: Recent data suggest that the glutamatergic system is important in the proliferation and migration of glioblastoma. Talampanel is a well-tolerated, oral α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blocker that could be beneficial in this disease. PATIENTS AND METHODS...

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Bibliographic Details
Main Authors: Grossman, Stuart A., Ye, Xiaobu, Chamberlain, Marc, Mikkelsen, Tom, Batchelor, Tracy, Desideri, Serena, Piantadosi, Steven, Fisher, Joy, Fine, Howard A.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2009
Subjects:
Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734427/
https://ncbi.nlm.nih.gov/pubmed/19636006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.21.6895
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