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Characterization of Novel Oxidation Products of Cysteine in an Active Site Motif Peptide of PTP1B

We investigated the formation of hydroxyl radical (OH(·)) and H(2)O(2) mediated oxidation products of a synthetic peptide, HCSAGIGRS, which is an active site sequence motif of protein tyrosine phosphatase 1B (PTP1B). We determined that a novel cysteine sulfinamide HC[S(O)N]SAGIGRS is produced in the...

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Bibliografiske detaljer
Main Authors: Shetty, Vivekananda, Neubert, Thomas A
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734337/
https://ncbi.nlm.nih.gov/pubmed/19464924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2009.04.011
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