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Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults

INTRODUCTION: Hereditary angioedema (HAE) is caused by mutations in the C1inh gene, leading to dysfunction of the C1-esterase inhibitor (C1-INH). C1-INH interacts with MASP-1 and MASP-2 proteases, participating in the mannan-binding lectin (MBL) pathway of complement activation. The aim of the study...

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Bibliografiske detaljer
Main Authors: Cedzyński, Maciej, Madaliński, Kazimierz, Gregorek, Hanna, Świerzko, Anna S., Nowicka, Ewa, Obtułowicz, Krystyna, Dzierżanowska-Fangrat, Katarzyna, Wojda, Urszula, Rabczenko, Daniel, Kawakami, Masaya
Format: Artigo
Sprog:Inglês
Udgivet: Birkhäuser-Verlag 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734250/
https://ncbi.nlm.nih.gov/pubmed/18250972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00005-008-0004-7
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