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Population Genomic Analysis of ALMS1 in Humans Reveals a Surprisingly Complex Evolutionary History
Mutations in the human gene ALMS1 result in Alström Syndrome, which presents with early childhood obesity and insulin resistance leading to Type 2 diabetes. Previous genomewide scans for selection in the HapMap data based on linkage disequilibrium and population structure suggest that ALMS1 was subj...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734137/ https://ncbi.nlm.nih.gov/pubmed/19279085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msp045 |
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