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Decreasing Efficacy of Antimalarial Combination Therapy in Uganda Explained by Decreasing Host Immunity Rather than Increasing Drug Resistance

BACKGROUND: Improved control efforts are reducing the burden of malaria in Africa, but may result in decreased antimalarial immunity. METHODS: A cohort of 129 children aged 1–10 years in Kampala, Uganda were treated with amodiaquine+sulfadoxine-pyrimethamine for 396 episodes of uncomplicated malaria...

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Detalhes bibliográficos
Main Authors: Greenhouse, Bryan, Slater, Madeline, Njama-Meya, Denise, Nzarubara, Bridget, Maiteki-Sebuguzi, Catherine, Clark, Tamara D., Staedke, Sarah G., Kamya, Moses R., Hubbard, Alan, Rosenthal, Philip J., Dorsey, Grant
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733854/
https://ncbi.nlm.nih.gov/pubmed/19199542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/596741
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