Impaired PGC-1α function in muscle in Huntington's disease

We investigated the role of PPAR γ coactivator 1α (PGC-1α) in muscle dysfunction in Huntington's disease (HD). We observed reduced PGC-1α and target genes expression in muscle of HD transgenic mice. We produced chronic energy deprivation in HD mice by administering the catabolic stressor β-guan...

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Detalhes bibliográficos
Main Authors: Chaturvedi, Rajnish K., Adhihetty, Peter, Shukla, Shubha, Hennessy, Thomas, Calingasan, Noel, Yang, Lichuan, Starkov, Anatoly, Kiaei, Mahmoud, Cannella, Milena, Sassone, Jenny, Ciammola, Andrea, Squitieri, Fernando, Beal, M. Flint
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733807/
https://ncbi.nlm.nih.gov/pubmed/19460884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp243
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