Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects

AIMS: To investigate the safety, pharmacokinetics and pharmacodynamics of rivaroxaban, an oral, direct Factor Xa (FXa) inhibitor, in healthy, male Chinese subjects. METHODS: Two randomized, single-blind, placebo-controlled, dose-escalation studies were conducted in healthy Chinese men aged 18–45 yea...

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Main Authors: Zhao, Xia, Sun, Peihong, Zhou, Ying, Liu, Yuwang, Zhang, Huilin, Mueck, Wolfgang, Kubitza, Dagmar, Bauer, Richard J, Zhang, Hong, Cui, Yimin
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2009
Teme:
Pharmacokinetic Dynamic Relationships
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732942/
https://ncbi.nlm.nih.gov/pubmed/19660005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03390.x
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