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Hierarchical hidden Markov model with application to joint analysis of ChIP-chip and ChIP-seq data

Motivation: Chromatin immunoprecipitation (ChIP) experiments followed by array hybridization, or ChIP-chip, is a powerful approach for identifying transcription factor binding sites (TFBS) and has been widely used. Recently, massively parallel sequencing coupled with ChIP experiments (ChIP-seq) has...

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Detalhes bibliográficos
Main Authors: Choi, Hyungwon, Nesvizhskii, Alexey I., Ghosh, Debashis, Qin, Zhaohui S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732365/
https://ncbi.nlm.nih.gov/pubmed/19447789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp312
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