Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn’s disease

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn’s disease (CD) is associated with SNPs around IRGM1,2, but coding-sequence variation has been exc...

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Bibliografiske detaljer
Main Authors: McCarroll, Steven A, Huett, Alan, Kuballa, Petric, Chilewski, Shannon D, Landry, Aimee, Goyette, Philippe, Zody, Michael C, Hall, Jennifer L, Brant, Steven R, Cho, Judy H, Duerr, Richard H, Silverberg, Mark S, Taylor, Kent D, Rioux, John D, Altshuler, David, Daly, Mark J, Xavier, Ramnik J
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731799/
https://ncbi.nlm.nih.gov/pubmed/19165925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.215
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