The Werner’s syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds

PURPOSE: Werner’s syndrome (WS) is a recessive disorder of premature onset of processes associated with aging. Defective DNA repair has been reported after exposure of cells isolated from WS patients to DNA-damaging agents. The germline 4330T>C (Cys1367Arg) variant in the WS gene (WRN) has been a...

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Main Authors: Innocenti, Federico, Mirkov, Snezana, Nagasubramanian, Ramamoorthy, Ramírez, Jacqueline, Liu, Wanqing, Bleibel, Wasim K., Shukla, Sunita J., Hennessy, Kathleen, Rosner, Gary L., Cook, Edwin, Dolan, M. Eileen, Ratain, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731557/
https://ncbi.nlm.nih.gov/pubmed/18677484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0793-8
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