Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men

OBJECTIVE: We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin. RESEARCH DESIGN AND METHODS: A total of 5,327 nondiabetic men (age 58 ± 7 years, BMI 27.0 ± 3.8 kg/m(...

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Main Authors: Stančáková, Alena, Kuulasmaa, Teemu, Paananen, Jussi, Jackson, Anne U., Bonnycastle, Lori L., Collins, Francis S., Boehnke, Michael, Kuusisto, Johanna, Laakso, Markku
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731523/
https://ncbi.nlm.nih.gov/pubmed/19502414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0117
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