Recombinant plasmepsin 1 from the human malaria parasite Plasmodium falciparum: Enzymatic characterization, active site inhibitor design, and structural analysis

A mutated form of truncated proplasmepsin 1 (proPfPM1) from the human malaria parasite Plasmodium falciparum, proPfPM1 K110pN, was generated and overexpressed in E. coli. The auto-maturation process was carried out at pH 4.0 and 4.5, and the optimal catalytic pH of the resulting mature PfPM1 was det...

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Bibliografiske detaljer
Main Authors: Liu, Peng, Marzahn, Melissa R., Robbins, Arthur H., Gutiérrez-de-Terán, Hugo, Rodríguez, David, McClung, Scott, Stevens, Stanley M., Yowell, Charles A., Dame, John B., McKenna, Robert, Dunn, Ben M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730762/
https://ncbi.nlm.nih.gov/pubmed/19271776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802059r
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