Caspase-12 and the Inflammatory Response to Yersinia pestis

BACKGROUND: Caspase-12 functions as an antiinflammatory enzyme inhibiting caspase-1 and the NOD2/RIP2 pathways. Due to increased susceptibility to sepsis in individuals with functional caspase-12, an early-stop mutation leading to the loss of caspase-12 has replaced the ancient genotype in Eurasia a...

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Detalhes bibliográficos
Main Authors: Ferwerda, Bart, McCall, Matthew B. B., de Vries, Maaike C., Hopman, Joost, Maiga, Boubacar, Dolo, Amagana, Doumbo, Ogobara, Daou, Modibo, de Jong, Dirk, Joosten, Leo A. B., Tissingh, Rudi A., Reubsaet, Frans A. G., Sauerwein, Robert, van der Meer, Jos W. M., van der Ven, André J. A. M., Netea, Mihai G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730527/
https://ncbi.nlm.nih.gov/pubmed/19721713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006870
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